Pharmacological pleiotropism of the human recombinant α 1A -adrenoceptor: implications for α 1 -adrenoceptor classification

Tamsulosin potently and selectively antagonizes human recombinant α(1A/1D)-adrenoceptors: slow dissociation from the α(1A)-adrenoceptor may account for selectivity for α(1A)-adrenoceptor over α(1B)-adrenoceptor subtype.

We determined the binding affinity of tamsulosin, a selective α(1)-adrenoceptor antagonist, for human α(1)-adrenoceptor subtypes in comparison with those of other α(1)-adrenoceptor antagonists including silodosin, prazosin, 5-methylurapidil, terazosin, alfuzosin, nafopidil, urapidil and BMY7378. The association and dissociation kinetics of [(3)H]tamsulosin for recombinant human α(1)-adrenocepto...

The role of CA1 α-adrenoceptor on scopolamine induced memory impairment in male rats

Introduction: Similarities in the memory impairment between Alzheimer patients and scopolamine treated animals have been reported. In the present study, the possible role of α-adrenergic receptors of the dorsal hippocampus on scopolamine state-dependent memory in adult male Wistar rats was evaluated. Methods: The animals were bilaterally implanted with chronic cannulae in the CA1 regions o...

CONTRACTIONS DUE TO α-ADRENOCEPTOR AGONISTS ARE MEDIATED BY α1-ADRENOCEPTORS IN RAT CAROTID ARTERY

Some large vessels have a mixed functional population of postjunctional α1- and α 2-adrenoceptors. The purpose of the work presented here was to investigate the population of postjunctional α -adrenoceptors in the rat isolated common carotid artelY Male Wi star rats were killed by overdose with pentobarbitone sodium, after which the left and right common carotid arteries were removed. Rings...

Α-adrenoceptor Blockade Modifies Neurally Induced Atrial Arrhythmias

1 Centre de recherche, Hôpital du Sacré-Cœur de Montréal, Montréal, Canada H4J 1C5 2 Department of Pharmacology, Faculty of Medicine, Université de Montréal, Montréal, Canada H3C 3J7 3 Department of Physiology, Faculty of Medicine, Université de Montréal, Montréal, Canada H3C 3J7 4 Department of Pharmacology, East Tennessee State University, James H. Quillen College of Medicine, Johnson City, T...

Multiple interactions between transmembrane helices generate the oligomeric α 1 b - adrenoceptor